West Virginia Gives Us The Finger
As has been noted here previously, Michigan is the most anthropomorphic state in the Union. We Michiganians are proud to show you where we live (or where we're from) by pointing to a spot on our hand.
I also think Florida is anthropomorphic... but I"m not going there.
However, in a recent NPR Wait Wait Don't Tell Me blog post about the Senators drawing their home states, Ian Chillag pointed out that his home state of West Virginia can also be represented by the human hand:
We have a unique way of representing our geography: you take your left hand, stick your thumb out to the side, and stick up your middle finger. There it is, The Mountain State, staring you in the face. It's especially useful for explaining West Virginia geography to someone who just cut you off in traffic.